Aim: The purpose of the present study was to investigate of the effectiveness of emotional intelligence training on the general health and self-esteem in adolescents with cerebral palsy. Methods: Study procedure was quasi-experimental with pretest-posttest design with control group. The study population included of adolescents with cerebral palsy aged 16-18 years old. Subjects were selected by convenient sampling method. In this study were participated 30 adolescents with cerebral palsy. Subjects were divided into two groups by randomly method (experimental and control group), each of which was consisted of 15 adolescents. Experimental group received in emotional intelligence training in the 12 sessions lasting for 50 minutes, but control group did not. The instrument of present research was Goldberg & Hiller general health guestionnaire and Cooper Smith self-esteem questionnaire. The obtained data were analyzed by using multivariate analysis of covariance (MANCOVA) test. Results: The findings of this research showed that there was significant increase in general health and self-esteem scores mean of experimental group in the post intervention in comparison with control group (P<0.0001). Conclusion: The emotional intelligence training program led to improve the general health and self-esteem of adolescents with cerebral palsy. Therefore, paying attention to the variables such as general health and self-esteem are essential and planning for providing of emotional intelligence training is a particular importance.